Composition: Each 1 ml contain:
Sulphadimidine sodium 330 mg
sulphadimidine Sodium is the active ingredient of AVISULPHA Injectable solution, Sulphadimidine like many sulphonamides in the sulfonamide group, has been utilized for decades in veterinary medicine, hence, the veterinary literature contains many reports on its usage in a wide variety of animals, including cattle, horses, swine, poultry, small ruminants and rabbits.
Sulphadimidine sodium and other sulphonamides have a similar structure to P-aminobenzoic acid (PABA) and interfere with the synthesis of nucleic acids in sensitive micro-organisms by blocking the conversion of PABA to the Co-enzyme dihydrofolic acid, a reduced form of folic acid, in man, dihydro- folic acid is obtained from dietary folic acid so sulphonamides do not affect human cells.
AVISULPHA has been shown to be effective in the treatment of coccidiosis and foul in the foot.
AVISULPHA has been shown to be effective in vitro against the following bacterial species: Actinobacillus lignier, Bordetella bronchiseptica, Escherichia coli, Mannheimia haemolytica, Salmonella Dublin, Salmonella typhimurium.
Target animals: cattle and sheep
Dosage and Administration:
By intravenous or subcutaneous injection.
Cattle and sheep: Initial Dose 200 mg/1 kg body weight every 24 hours for 5 days. (Equivalent to 100 ml per 150 Kg b.wt.).
Maintenance Dose 100 ml/1kg body weight every 24 hours for 5 days.
(Equivalent to 50 ml per 150 Kg b.wt.) Withdrawal Period:
Meat: 8 days
Milk: Not for use in animals producing milk for human consumption.
Contraindicated in known cases of hypersensitivity to sulphonamides and in animals with severe liver damage or blood dyscrasias.
To minimize the risk of injection site tissue reaction following subcutaneous administration it is recommended that the dose be divided, administered at separate sites and well massaged.
Maximum recommended volume administered at a single site:
Cattle: 50 ml sheep: 10 ml
Due to likely variability (time, geographical) in the occurrence of resistant bacteria for sulfadimidine, bacteriological sampling and susceptibility testing are recommended.
Adequate water must be available during period of treatment. Particular care must be taken in the case of animals suffering from renal damage.
Store in a dark place at a temperature below 30C.
20, 50 & 100 ml sterile glass bottles.
FOR VETERINARY USE ONLY